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Liberty BlueMicrowave assisted peptide synthesis has become the new gold standard in solid phase peptide synthesis, and CEM Corporation offers a complete line of products for all your peptide synthesis needs. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis. CEM is the only company that supplies peptide synthesizers that utilize microwave energy for the complete peptide synthesis process. No other synthesizer on the market can provide the use of microwave energy for both the coupling and deprotection steps, making the CEM microwave peptide synthesizers the most versatile and powerful systems available.
CEM microwave peptide synthesizers have several advantages over conventional peptide synthesizers:
  • License included with each system allowing the use of microwave energy for both the coupling and deprotection steps
  • Fastest cycle times available
  • Unparalleled peptide purity and yield compared to conventional synthesis
  • Significantly reduces purification time and waste
  • Access to peptides impossible to synthesize under conventional conditions
US7393920; US7582728; US8058393; EP1491552; JP4773695
Additional worldwide patents pending

On-Demand Webinar: Fast, Sequential Peptide Synthesis 

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Featured Article
High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS)
by Jonathan M. Collins *, Keith A. Porter , Sandeep K. Singh , and Grace S. Vanier
Org. Lett., 2014, 16 (3), pp 940–943
DOI: 10.1021/ol4036825
Publication Date (Web): January 23, 2014
Featured Chemistry
The epidermal growth factor receptor variant III (EGFRvIII) is a consistent and tumor-specific mutation present in many forms of cancer, making this an attractive target for antitumor immunotherapy. An EGFRvIII-targeted peptide conjugated to keyhole limpet hemocyanin has been identified as a tumor-specific vaccine. The synthesis of the EGFRvIII peptide has been shown to suffer from slow Fmoc deprotection rates and therefore reduced peptide purity. Read about the impact of microwave technology on the synthesis of the EGFRvIII peptide with a critical assessment of the use of microwave irradiation for each step of the synthesis.   [Read Technical Note]

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Related Products

With 4-minute cycle times and a 90% reduction in solvent usage, Liberty Blue is the fastest and most efficient research scale peptide synthesizer available. Blue offers greater flexibility, better yields and purities, and improved reliability over conventional and first generation microwave peptide synthesizers.


Make up to 24 high-purity peptides sequentially in a fraction of the time it would take using conventional parallel peptide synthesis.


With cycle times of less than 30 minutes, generate hundreds of grams of peptides in a fraction of the time it would take to prepare conventionally. Methods transfer easily from our Liberty Blue System.

Manual Microwave Peptide Synthesizer
Discover Bio is a full-featured flexible system that can be used for peptide synthesis and small molecule organic synthesis. This compact, entry-level system is easily upgradeable to an automated Liberty Blue System.



Fmoc Amino Acids

Purchase pre-weighed Fmoc amino acids in CEM centrifuge tubes and take full advantage of the speed and efficiency of your Liberty Blue. Centrifuge tubes with 2.5 or 5.0 mmol are ready for dilution and direct installation on the Liberty Blue, Liberty Blue HT, and Liberty Lite synthesizers.


SpheriTide polymeric microspheres for solid phase peptide synthesis consist of poly-E-lysine cross-linked with multifunctional carboxylic acids. It possesses a hydrophilic character specifically designed to reduce intra-molecular aggregation, a known problem in SPPS; this peptidic nature results in higher peptide purities and yields. SpheriTide is fully compatible with both microwave, and conventional, peptide synthesis chemistries.