Microwave Peptide Synthesis


Liberty Blue CEM understands peptide synthesis. From resins proven to increase product purity to instruments that shorten reaction times while increasing peptide yield to cleavage systems that remove peptides at the speed of light, CEM has the solution.

Microwave assisted peptide synthesis has become the standard in solid phase peptide synthesis. High efficiency SPPS (HE-SPPS) takes the power of microwave energy and uses it to shorten cycle times to only 4 minutes while reducing the amount of waste generated. CEM is the only company that supplies peptide synthesizers that utilize HE-SPPS conditions. No other synthesizer on the market can provide the use of microwave energy for both the coupling and deprotection steps, making the CEM microwave peptide synthesizers the most versatile and powerful systems available.
CEM microwave peptide synthesizers have several advantages over conventional peptide synthesizers:
  • License included with each system allowing the use of microwave energy for both the coupling and deprotection steps
  • Fastest cycle times available
  • Unparalleled peptide purity and yield compared to conventional synthesis
  • Significantly reduces purification time and waste
  • Access to peptides impossible to synthesize under conventional conditions
US7393920; US7582728; US8058393; EP1491552; JP4773695
Additional worldwide patents pending



Related Products

With 4-minute cycle times and a 90% reduction in solvent usage, Liberty Blue is the fastest and most efficient research scale peptide synthesizer available. Blue offers greater flexibility, better yields and purities, and improved reliability over conventional and first generation microwave peptide synthesizers.


Make up to 24 high-purity peptides sequentially in a fraction of the time it would take using conventional parallel peptide synthesis.


With cycle times of less than 30 minutes, generate hundreds of grams of peptides in a fraction of the time it would take to prepare conventionally. Methods transfer easily from our Liberty Blue System.

Manual Microwave Peptide Synthesizer
Discover Bio is a full-featured flexible system that can be used for peptide synthesis and small molecule organic synthesis. This compact, entry-level system is easily upgradeable to an automated Liberty Blue System.



Fmoc Amino Acids

Purchase pre-weighed Fmoc amino acids in CEM centrifuge tubes and take full advantage of the speed and efficiency of your Liberty Blue. Centrifuge tubes with 2.5 or 5.0 mmol are ready for dilution and direct installation on the Liberty Blue and Liberty Blue HT synthesizers.

SpheriTide® Resins

SpheriTide polymeric microspheres for solid phase peptide synthesis consist of poly-ε-lysine cross-linked with multifunctional carboxylic acids. It possesses a hydrophilic character specifically designed to reduce intra-molecular aggregation, a known problem in SPPS; this peptidic nature results in higher peptide purities and yields. SpheriTide is fully compatible with both microwave and conventional peptide synthesis.

SpheriTide® is a registered trademark of SpheriTech Ltd.